The original manuscript has been lost.

原稿已经遗失。

《牛津词典》

I want to revise my original manuscript.

我想修改原先的手稿。

youdao

She collated the final proof with the original manuscript.

她将清样与原稿核对。

youdao

Historical records show that five copies of the original manuscript were made under the supervision of Rashid al-Din.

UNESCO: Memory of the World

The readings will be taken from the original manuscript found on Plath's desk after her death aged 30.

BBC: Sylvia Plath performance planned for Literature Festival

The original manuscript of her Diary, published in 2008, will be presented, as well as many family archives.

UNESCO: CULTURE